Patient Success Cases

POOR OVARIAN RESPONDER

A 31 yrs. Indian patient had two healthy children followed by two miscarriages and then a period of no pregnancy. She now had a low AMH and underwent an IVF cycle in India with a very poor response and no pregnancy. She was referred to Dr Nisarath Soontrapa at Superior A.R.T. who modified her ovarian stimulation and recommend comprehensive chromosome screening using NGS. She had one cycle with the modified stimulation protocol with 15 eggs collected and seven good embryos for NGS analysis.

The NGS resulted in only two embryos with apparently good chromosomes, the high rate of chromosomal aneuploidy (defects) showing why she had two miscarriages and a period of no pregnancy. One good embryo was transferred resulting in a healthy pregnancy. The patients Indian doctor said “Dr Nisarath is a genius”.

FAILED IVF AND MISCARRIAGE

Patient Mrs I., 42 yrs. old, from Thailand presented at Superior A.R.T. and Dr Weena Krutsawad after having one miscarriage and three failed IVF cycles at other clinics.

She was now 42 years old and had a very low AMH. After a series of tests, Dr Weena stimulated Mrs I., resulting in 4 eggs collected and 3 good embryos tested by PGD-NGS.

One embryo was chromosomally normal, transferred, and Mrs I. had a healthy pregnancy and a healthy baby. Mrs I. said she was so happy with the excellent care, attention to detail, and the expertise of doctor, nurse, scientists and all staff at Superior A.R.T.

X-LINKED / SCID

Patient Mrs T., 41 yrs old, from Thailand presented at Superior A.R.T. after having given birth to a son with a rare severe X-Linked gene disorder, “Severe Combined Immunodeficiency Disease (SCID)”.

Superior A.R.T. Genetics counselled the patient and build a PGD-PCR test for the SCID disorder. Under the care of Dr Weena Krutsawad, Mrs T. had two stimulation cycles with combined PGD-NGS and PGD -PCR. A total of 7 embryos were tested resulting in 2 embryos that were both chromosomally normal and free of the SCID disorder.

One embryo was transferred, and Mrs T. had a healthy pregnancy and a healthy baby. Mrs T. was overjoyed that such expertise, advanced technology, and super care was available allowing her and her husband to have a healthy baby.

X-LINKED / DMD

Patient NL, 29 years old from Vietnam, consulted with Dr Nisarath at Superior A.R.T. due to a family history of X-linked Duchene muscular dystrophy (DMD), of which she was a carrier. Superior A.R.T. built a PGD Genetics test for the family before NL had one stimulation cycle producing 15 eggs with four good embryos biopsied for PGD-PCR analysis.

The PGD-PCR resulted in three unaffected embryos, with one good embryo transferred resulting in a healthy pregnancy and a healthy baby. Following the birth NL had a second good frozen embryo transferred resulting in another healthy birth. NL and her husband were overjoyed at having two healthy babies unaffected by the crippling family disease.

OVARIAN RESERVE

Patient K, 37 years old from Thailand approached Superior A.R.T. after another clinic refused to treat her because of her very low AMH and long history of infertility. Dr Weena counselled the patient that she had a chance of success with her own eggs, and recommended doing PGD-NGS. K. underwent two ovarian stimulations cycles resulting in 3 embryos and 2 embryos being biopsied and tested by PGD-NGS. Two embryos of the five embryos were apparently chromosomally normal, and both transferred to K. resulting in the birth of a single healthy baby boy. K. was thrilled that she came to Superior A.R.T. and was given the chance to use her own eggs to have the baby they dreamed off.

They have a son with HbH/CS disease

Patient D, a 31-year-old Northern Thai woman whose son diagnosed with HbH/CS disease (–/-αCS) which requiring blood transfusion, came for the PGD assistance program. The patient and her husband wanted to have an Alpha Thalassemia free HLA matched baby to cure their affected son.

At Superior A.R.T. , after determining – she had a high ovarian reserve and normal uterine lining, the patient underwent a cycle of COS using a GnRH antagonist protocol.

Unfortunately, they had no matched embryo from 15 tested embryos in the first COS cycle. Two months later, in the second cycle, they got one carrier matched embryo from 11 biopsied embryos. Following embryo transfer, the hCG rose, fetal heart was detected, and she gave birth to a healthy boy in May 2019.

Their son suffered from beta Thalassemia

Patient S, a Thai patient aged 36 years old has a son who is suffering from Beta0 Codon 41/42 (-CTTT)/HbE Thalassemia requiring a blood transfusion every 3 months. She wanted a HLA matched baby to cure her son using cord blood stem cell transplantation.

At Superior A.R.T., a check-up determined normal ovarian reserve and the patient underwent a cycle of COS using a GnRH antagonist protocol. The second cycle had one carrier matched embryo from 5 biopsied embryos. After a Hysteroscopic Polypectomy and embryo transfer the hCG rose, fetal heart was detected, and she gave birth to a healthy boy in September 2019.

They suffered from a miscarriage and two medical terminations of pregnancy

Patient P, a Thai patient aged 33 years old, suffered from medical termination twice due to having Hb Bart’s Hydrop Fetalis pregnancy.

At Superior A.R.T., a check-up determined normal ovarian reserve and the patient underwent a cycle of COS with a GnRH antagonist protocol. They had one normal embryo and 4 carrier embryos from the first COS cycle, but were unsuccessful in 2 cycles of FTE/ET. Following a Hysteroscopic diagnosis and a further FET cycle, the hCG rose and fetal heart was detected, and she gave birth to a healthy girl in November 2019.